Microbial biotransformation of aryl sulfanylpentafluorides
نویسندگان
چکیده
منابع مشابه
Microbial biotransformation products of cyclosporin A.
In order to mimic the human metabolic pathway of cyclosporin A (CyA) a total of 28 bacterial and 72 fungal strains was screened for their ability to transform CyA. Among 3 bacteria and 11 fungi, which produced the main human metabolite OL-17 [eta HyMeBmt1]CyA, Actinoplanes sp. (ATCC 53771) achieved the best transformation rate (5.4%). Furthermore, the two N-demethylated minor products [Leu4]CyA...
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Microbial transformation is a complementary tool in the investigation of drug metabolism. In the present investigation, biotransformation of vincamine was studied using microbial cultures. Bacterial, fungal, and yeast cultures were employed to elucidate the metabolism of vincamine. The results indicate that a number of microorganisms metabolized vincamine to various levels to yield three major ...
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Antifungal drugs belong to few chemical groups and such low diversity limits the therapeutic choices. The urgent need of innovative options has pushed researchers to search new bioactive molecules. Literature regarding the last 15 years reveals that different research groups have used different approaches to achieve such goal. However, the discovery of molecules with different mechanisms of act...
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متن کاملMicrobial Biotransformation: A Process for Chemical Alterations
Biotransformations are structural modifications in a chemical compound by organisms /enzyme systems that lead to the formation of molecules with relatively greater polarity [1,2]. This mechanism has been developed by microbes to acclimatize to environmental changes and it is useful in a wide range of biotechnological processes [3]. The most significant aspect of biotransformation is that it mai...
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ژورنال
عنوان ژورنال: Environmental Science and Pollution Research
سال: 2013
ISSN: 0944-1344,1614-7499
DOI: 10.1007/s11356-013-1985-2